منابع مشابه
Adjuvant therapy for colon and rectal cancer.
Newly diagnosed colon or rectal cancer should be staged using the TNM (tumor, node and distant metastasis) nomenclature to determine prognostic factors. Based on this staging, it is possible to select patients in need of adjuvant therapy following surgery. In patients with stage III colon cancer, adjuvant chemotherapy with fluorouracil and levamisole has been shown to produce a 40 percent reduc...
متن کاملManaging choices for older patients with colon cancer: adjuvant therapy.
Colon cancer is among the most common cancers in the United States, and the median age of patients at diagnosis is 70. Medical oncologists are commonly asked to comprehensively evaluate elderly patients to estimate individual risk/benefit ratios for adjuvant treatment. Although 40% of patients with colon cancer are elderly, clinical trials enroll mainly younger patients. Consequently, we are fo...
متن کاملAdjuvant chemotherapy for colon cancer.
Surgery remains the only curative therapy for colon cancer. However, several studies during the last years have proved that systemic chemotherapy in the adjuvant setting definitely improves the curative rate for those patients with localized colon cancer. The combination of 5-fluorouracil (5-FU) and leukovorin (LV) remained the reference treatment for over a decade. However, oxaliplatin-based c...
متن کاملAdjuvant Systemic Therapy in Stage II and III Colon Cancer
The prognosis of colon cancer is primarily determined through staging of the disease. After curative surgery, clinically occult micrometastases are thought to be the major source of disease recurrence. The main aim of postoperative systemic treatment is to eradicate micrometastases, thereby improving outcomes with an increased cure rate. Adjuvant systemic chemotherapy is indicated for patients ...
متن کاملNew approaches to the adjuvant therapy of colon cancer.
Analysis of data from patients treated outside clinical trials suggests that adjuvant chemotherapy for stage II colon cancer provides less than a 3% absolute improvement in survival at 5 years. This is remarkably close to the small degree of benefit suggested by controlled studies. An overview of the data suggests that surgery alone cures approximately 75% of stage II patients. Between 20% and ...
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ژورنال
عنوان ژورنال: CA: A Cancer Journal for Clinicians
سال: 1997
ISSN: 0007-9235
DOI: 10.3322/canjclin.47.4.243